Understanding VYALEV®
(foslevodopa/foscarbidopa)
Understanding VYALEV®
(foslevodopa/
foscarbidopa)
What is VYALEV?
VYALEV is a medicine containing two active ingredients, foslevodopa and foscarbidopa.
It is used to treat advanced Parkinson’s disease (PD), helping you to gain control over your movements and posture.
How does VYALEV work?
VYALEV, comprising of foslevodopa and foscarbidopa, are made into levodopa and carbidopa, respectively.
- Once in the body, levodopa is made into a chemical called dopamine, which plays an important role for smooth, controlled body movements. PD occurs when the nerve cells in the brain don’t with foslevodopa helps to increase the amount of dopamine in the brain.
- Carbidopa helps to improve the effect of levodopa by preventing the breakdown of levodopa in the bloodstream, so more levodopa can enter the brain (where it is needed). Carbidopa also reduces the side effects of levodopa.
For people with PD, this helps to reduce PD signs such as tremor, stiffness, slow movement and problem keeping balance.
How is VYALEV administered?
The foslevodopa and foscarbidopa solution is administered under the skin (subcutaneously), most frequently on the abdomen (belly) using the VYAFUSER® Pump. The pump delivers the medicine to your body continuously for 24 hours a day.
VYALEV and its supporting items
Solution vial
Each pack contains 7 glass vials, with each vial containing 10 mL of VYALEV solution.
Vial adapter
Attaches to the solution vial and is used to transfer your medicine from the vial to the syringe.
Syringe
Used for drawing up your medicine and is used in your pump to deliver your VYALEV solution.
Tubing
Connects your syringe in the pump to the infusion site to deliver your medicine.
Insertion device
Used to insert your cannula into your body. The cannula is a small plastic tube that allows your medicine to flow into your body.
VYAFUSER® Pump
Delivers VYALEV solution from the syringe through the infusion set tubing and into the infusion site.
Batteries
Used as the power source for operating your pump.
Note: The battery should be recharged at least once a day. You will receive two batteries with your VYALEV.
Battery charger and adapter
Used to charge one battery while the other is in use.
Disposable container*
Used to dispose of any used medical items. Learn more about safe disposal of VYALEV on Using VYALEV page.
Paper towels*
Used to help to keep a clean surface for administering VYALEV.
Alcohol pads
Used to help clean the infusion site on your skin and keep the items sterile.
*Items not provided.
Watch this video to
learn more about VYALEV
and how it works
Download the digital
version of the Getting
Started with
VYALEV booklet
AU-ABBV-230284. AC-004199-02. July 2025.